Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1372)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0988566	0.1071366	0.3666362
Weighted median	23	0.0362927	0.0537683	0.4996862
Inverse variance weighted	23	0.0280329	0.0414115	0.4984464
Simple mode	23	0.0663614	0.0799832	0.4156258
Weighted mode	23	0.0374288	0.0589210	0.5318264

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.19079	21	0.2839063
Inverse variance weighted	24.78496	22	0.3074685

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043493	0.0060559	0.4805549

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007667	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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