Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1371)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0586892	0.1063869	0.5870054
Weighted median	23	0.1036246	0.0576651	0.0723346
Inverse variance weighted	23	0.1031362	0.0408249	0.0115268
Simple mode	23	0.1445489	0.1016314	0.1689675
Weighted mode	23	0.0965654	0.0679856	0.1695150

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.85410	21	0.3001814
Inverse variance weighted	24.08812	22	0.3426274

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027295	0.0060135	0.6545622

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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