Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1370)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0872300	0.0998210	0.3920762
Weighted median	23	-0.0249777	0.0550609	0.6500898
Inverse variance weighted	23	-0.0647381	0.0390156	0.0970582
Simple mode	23	-0.1336350	0.0875663	0.1412340
Weighted mode	23	-0.0143870	0.0574530	0.8045910

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.34207	21	0.8544622
Inverse variance weighted	17.07771	22	0.7590582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093323	0.0056423	0.1130039

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006009	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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