Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 137)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1269361	0.0998210	0.2174057
Weighted median	23	0.0275949	0.0572801	0.6299814
Inverse variance weighted	23	0.0421126	0.0390156	0.2804189
Simple mode	23	0.0784900	0.1016114	0.4480660
Weighted mode	23	0.0513562	0.0644508	0.4340663

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.92321	21	0.8728748
Inverse variance weighted	14.77550	22	0.8716908

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005209	0.0056424	0.3663926

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000483	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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