Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1369)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0128946	0.1300260	0.9219447
Weighted median	23	0.0433521	0.0641372	0.4990864
Inverse variance weighted	23	-0.0241590	0.0496640	0.6266481
Simple mode	23	0.0603654	0.1255596	0.6354262
Weighted mode	23	0.0819253	0.1195778	0.5004230

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.63409	21	0.024026
Inverse variance weighted	35.64912	22	0.033100

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006918	0.0073498	0.9259062

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010918	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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