Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1368)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1562355	0.1053021	0.1527464
Weighted median	23	-0.0127986	0.0545732	0.8145803
Inverse variance weighted	23	0.0347742	0.0437721	0.4269398
Simple mode	23	0.0506130	0.1115501	0.6544713
Weighted mode	23	-0.0306188	0.0616155	0.6241654

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.36967	21	0.3245897
Inverse variance weighted	27.69149	22	0.1861320

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0117299	0.0059522	0.0620847

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008631	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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