Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1367)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0514540	0.0998210	0.6116140
Weighted median	23	0.0577410	0.0558727	0.3013991
Inverse variance weighted	23	0.0082437	0.0390158	0.8326607
Simple mode	23	0.0567889	0.0957693	0.5592442
Weighted mode	23	0.0517500	0.0665723	0.4452307

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.10464	21	0.8650626
Inverse variance weighted	14.32581	22	0.8895132

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026535	0.0056424	0.6429961

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004355	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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