Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1366)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0126247	0.0998209	0.9005602
Weighted median	23	0.0087086	0.0522908	0.8677306
Inverse variance weighted	23	0.0194510	0.0390158	0.6181021
Simple mode	23	0.0411566	0.0867843	0.6400017
Weighted mode	23	-0.0043109	0.0596286	0.9430194

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.37911	21	0.5608345
Inverse variance weighted	19.50099	22	0.6142229

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019698	0.0056423	0.7304876

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005985	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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