Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1365)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1915952	0.1129969	0.1047429
Weighted median	23	-0.0864540	0.0541536	0.1103860
Inverse variance weighted	23	-0.0053117	0.0463292	0.9087223
Simple mode	23	-0.0859999	0.0944492	0.3724057
Weighted mode	23	-0.1071969	0.0554130	0.0660136

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.91065	21	0.1738302
Inverse variance weighted	31.02140	22	0.0956785

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0114396	0.0063871	0.0877114

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009405	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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