Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1364)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0868795	0.1292456	0.5087822
Weighted median	23	0.0185289	0.0613230	0.7625355
Inverse variance weighted	23	-0.0058604	0.0498976	0.9065054
Simple mode	23	0.0923405	0.1035442	0.3821518
Weighted mode	23	0.0328238	0.0733384	0.6588420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.20701	21	0.0267928
Inverse variance weighted	35.98460	22	0.0304818

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049754	0.0073056	0.503288

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001091	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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