Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1363)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0235752	0.1130899	0.8368753
Weighted median	23	0.0759775	0.0547198	0.1649902
Inverse variance weighted	23	0.0491815	0.0432479	0.2554541
Simple mode	23	0.0983882	0.0858365	0.2640159
Weighted mode	23	0.0814782	0.0596574	0.1858130

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.95435	21	0.1723694
Inverse variance weighted	27.03202	22	0.2100129

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015725	0.0063924	0.8080758

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008673	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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