Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1362)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0262288	0.0998208	0.7952969
Weighted median	23	0.0084936	0.0557342	0.8788758
Inverse variance weighted	23	0.0365968	0.0390157	0.3482435
Simple mode	23	0.0245850	0.0924403	0.7927504
Weighted mode	23	0.0194127	0.0599584	0.7491707

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.29034	21	0.5665211
Inverse variance weighted	19.75789	22	0.5981811

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038581	0.0056423	0.5015914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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