Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1361)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1857790	0.0998200	0.0767832
Weighted median	23	-0.0560242	0.0534982	0.2949993
Inverse variance weighted	23	-0.0478167	0.0390155	0.2203563
Simple mode	23	0.0534668	0.0910117	0.5628690
Weighted mode	23	-0.0601614	0.0587587	0.3170230

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.17105	21	0.9348844
Inverse variance weighted	14.42573	22	0.8856832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084723	0.0056423	0.1480991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004827	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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