Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1360)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0702526	0.0998208	0.4892961
Weighted median	23	-0.0535585	0.0570954	0.3482174
Inverse variance weighted	23	-0.0423793	0.0390156	0.2773840
Simple mode	23	-0.0560416	0.0944287	0.5589121
Weighted mode	23	-0.0464278	0.0743007	0.5384882

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.07622	21	0.5802503
Inverse variance weighted	20.57895	22	0.5468735

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069167	0.0056424	0.233823

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006594	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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