Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 136)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0821175	0.1133694	0.4768531
Weighted median	23	0.1131710	0.0608522	0.0629182
Inverse variance weighted	23	0.1265313	0.0472340	0.0073882
Simple mode	23	0.2852659	0.1111637	0.0176141
Weighted mode	23	0.1276593	0.0646816	0.0611107

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.08842	21	0.1679457
Inverse variance weighted	32.24548	22	0.0733061

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0128131	0.0064082	0.0586592

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012958	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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