Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1359)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0486706	0.0998207	0.6308989
Weighted median	23	-0.0332959	0.0553592	0.5475390
Inverse variance weighted	23	-0.0111298	0.0390155	0.7754395
Simple mode	23	-0.0328782	0.0979416	0.7402833
Weighted mode	23	-0.0303482	0.0746463	0.6882589

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.00164	21	0.7110068
Inverse variance weighted	17.16858	22	0.7539894

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023054	0.0056424	0.6869818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005227	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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