Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1358)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0494453	0.1172512	0.6775262
Weighted median	23	0.0573346	0.0545030	0.2928209
Inverse variance weighted	23	0.0521525	0.0457098	0.2538919
Simple mode	23	0.0897312	0.1099391	0.4231415
Weighted mode	23	0.0224414	0.0632777	0.7262289

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.97473	21	0.1146095
Inverse variance weighted	30.19747	22	0.1137433

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062391	0.0066276	0.3572125

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009692	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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