Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1357)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0413331	0.1157675	0.7246278
Weighted median	23	0.0374220	0.0549663	0.4959872
Inverse variance weighted	23	0.0025017	0.0443478	0.9550150
Simple mode	23	0.1342422	0.0957997	0.1750802
Weighted mode	23	0.0362420	0.0638592	0.5761003

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.24587	21	0.1333149
Inverse variance weighted	28.42449	22	0.1620364

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023846	0.0065437	0.7191918

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008615	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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