Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1356)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1541482	0.0998206	0.1374638
Weighted median	23	0.0882297	0.0553576	0.1109781
Inverse variance weighted	23	0.0581209	0.0390157	0.1363083
Simple mode	23	0.1000945	0.0894007	0.2749520
Weighted mode	23	0.0954654	0.0582746	0.1156046

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.92620	21	0.8727484
Inverse variance weighted	15.01852	22	0.8614421

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005897	0.0056424	0.3078405

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005224	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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