Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1355)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0340729	0.0998208	0.7362386
Weighted median	23	-0.0313002	0.0541213	0.5630388
Inverse variance weighted	23	-0.0020168	0.0390160	0.9587736
Simple mode	23	-0.0268142	0.0791524	0.7379975
Weighted mode	23	-0.0325217	0.0618571	0.6043176

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.15835	21	0.8149234
Inverse variance weighted	15.28007	22	0.8499409

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019686	0.0056423	0.7306451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004631	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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