Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1354)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0453374	0.0998209	0.6543533
Weighted median	23	-0.0348617	0.0544680	0.5221458
Inverse variance weighted	23	-0.0319766	0.0390157	0.4124542
Simple mode	23	-0.0777674	0.0854723	0.3727595
Weighted mode	23	-0.0323322	0.0618089	0.6061342

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.19749	21	0.6990671
Inverse variance weighted	17.21864	22	0.7511806

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008205	0.0056423	0.8857696

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005421	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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