Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1353)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2453400	0.0998204	0.0227547
Weighted median	23	0.0709837	0.0529361	0.1799424
Inverse variance weighted	23	0.0449174	0.0390157	0.2496226
Simple mode	23	0.1053389	0.0947188	0.2780910
Weighted mode	23	0.0772884	0.0680430	0.2682310

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.968702	21	0.9793153
Inverse variance weighted	14.727021	22	0.8736841

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.012308	0.0056424	0.0406679

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8