Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1352)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0421323	0.0998203	0.6772552
Weighted median	23	-0.0108378	0.0572231	0.8497831
Inverse variance weighted	23	-0.0098331	0.0390155	0.8010180
Simple mode	23	-0.0191176	0.0882795	0.8305484
Weighted mode	23	-0.0101680	0.0655002	0.8780511

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.45173	21	0.4928314
Inverse variance weighted	20.57531	22	0.5470999

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019835	0.0056423	0.7286872

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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