Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1351)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1071131	0.1030964	0.3106383
Weighted median	23	-0.0395522	0.0591640	0.5038033
Inverse variance weighted	23	-0.0662785	0.0395429	0.0937157
Simple mode	23	-0.2382491	0.1136299	0.0477361
Weighted mode	23	-0.1202659	0.0747653	0.1219657

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.40178	21	0.3766830
Inverse variance weighted	22.59930	22	0.4246423

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025077	0.0058275	0.6713519

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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