Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1350)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0089082	0.1139705	0.9384393
Weighted median	23	-0.0326801	0.0545709	0.5492693
Inverse variance weighted	23	-0.0471559	0.0436597	0.2801073
Simple mode	23	-0.0403682	0.0891629	0.6551646
Weighted mode	23	-0.0262180	0.0602305	0.6675891

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.37600	21	0.1587516
Inverse variance weighted	27.54929	22	0.1911028

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023488	0.0064421	0.7190581

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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