Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 135)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0664374	0.0998203	0.5129306
Weighted median	23	0.0070186	0.0566312	0.9013667
Inverse variance weighted	23	-0.0013109	0.0390155	0.9731961
Simple mode	23	0.0153169	0.0949381	0.8733013
Weighted mode	23	0.0366983	0.0620522	0.5602736

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.88122	21	0.4662187
Inverse variance weighted	21.42492	22	0.4946272

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041604	0.0056423	0.4690634

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006493	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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