Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1349)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0558225	0.1045742	0.5990804
Weighted median	23	-0.0676973	0.0591595	0.2524922
Inverse variance weighted	23	-0.0001565	0.0402507	0.9968987
Simple mode	23	-0.0693789	0.1054009	0.5172147
Weighted mode	23	-0.0784219	0.0778442	0.3246847

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.04815	21	0.3414166
Inverse variance weighted	23.41522	22	0.3786103

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034185	0.0059111	0.5692016

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007095	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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