Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1348)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1499393	0.1163169	0.2113972
Weighted median	23	-0.1093728	0.0608156	0.0721083
Inverse variance weighted	23	-0.0441617	0.0454391	0.3311059
Simple mode	23	-0.1257167	0.1338384	0.3577673
Weighted mode	23	-0.1914172	0.1072221	0.0880179

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.51685	21	0.1260925
Inverse variance weighted	29.84236	22	0.1223466

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064959	0.0065749	0.3344076

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009431	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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