Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1347)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0562666	0.1230647	0.6522136
Weighted median	23	-0.0563826	0.0572318	0.3245440
Inverse variance weighted	23	-0.0372607	0.0470265	0.4281662
Simple mode	23	-0.1237471	0.0870407	0.1691316
Weighted mode	23	-0.0819212	0.0606719	0.1906698

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.91947	21	0.0596583
Inverse variance weighted	31.96226	22	0.0780417

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011672	0.0069562	0.8683572

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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