Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1346)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0575003	0.1264293	0.6539184
Weighted median	23	-0.0082391	0.0589986	0.8889372
Inverse variance weighted	23	-0.0366911	0.0490265	0.4542228
Simple mode	23	0.0099914	0.0950405	0.9172268
Weighted mode	23	0.0099914	0.0631797	0.8757867

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.68815	21	0.0391220
Inverse variance weighted	34.73910	22	0.0412458

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057842	0.0071463	0.4273624

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010794	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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