Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1345)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0549083	0.1265454	0.6687844
Weighted median	23	0.0018767	0.0565768	0.9735380
Inverse variance weighted	23	-0.0251822	0.0483987	0.6028495
Simple mode	23	-0.0562622	0.0947733	0.5588010
Weighted mode	23	0.0004055	0.0584027	0.9945224

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.74983	21	0.0385362
Inverse variance weighted	33.85450	22	0.0508228

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018255	0.0071529	0.8010467

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010385	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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