Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1344)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1589846	0.1071511	0.1527320
Weighted median	23	0.0838442	0.0556831	0.1321346
Inverse variance weighted	23	0.0606405	0.0418755	0.1475851
Simple mode	23	0.0975966	0.0862573	0.2700452
Weighted mode	23	0.0809772	0.0671559	0.2407002

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.19800	21	0.2835640
Inverse variance weighted	25.34368	22	0.2809236

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0060393	0.0060567	0.3300535

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008412	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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