Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1343)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0318840	0.1001748	0.7534135
Weighted median	23	0.0080145	0.0570553	0.8882892
Inverse variance weighted	23	0.0385633	0.0390156	0.3229532
Simple mode	23	0.0544411	0.0889673	0.5468621
Weighted mode	23	0.0241364	0.0634449	0.7072740

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.14922	21	0.4498640
Inverse variance weighted	21.15451	22	0.5112076

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004102	0.0056623	0.9429379

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006706	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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