Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1342)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0124696	0.0998208	0.9017748
Weighted median	23	0.0284057	0.0547088	0.6036100
Inverse variance weighted	23	0.0434050	0.0390159	0.2659242
Simple mode	23	0.0161140	0.0809934	0.8441256
Weighted mode	23	0.0475176	0.0594100	0.4323638

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.74593	21	0.8802633
Inverse variance weighted	14.11574	22	0.8973204

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034312	0.0056423	0.5496252

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004652	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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