Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1341)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1436229	0.1383872	0.3111506
Weighted median	23	0.0540456	0.0570838	0.3437528
Inverse variance weighted	23	0.0282454	0.0550891	0.6081460
Simple mode	23	0.0999466	0.1021937	0.3387018
Weighted mode	23	0.0428291	0.0625872	0.5009246

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.36280	21	0.0067163
Inverse variance weighted	43.86193	22	0.0036902

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0105544	0.0078223	0.191619

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013449	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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