Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1340)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0607533	0.0998201	0.5492984
Weighted median	23	0.0855804	0.0518590	0.0988916
Inverse variance weighted	23	0.0560949	0.0390159	0.1505069
Simple mode	23	0.1064065	0.0773628	0.1828450
Weighted mode	23	0.0740018	0.0610288	0.2381542

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.73894	21	0.5378471
Inverse variance weighted	19.74151	22	0.5992053

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002861	0.0056423	0.960042

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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