Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 134)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0252424	0.1071316	0.8160095
Weighted median	23	0.0244263	0.0602354	0.6851002
Inverse variance weighted	23	0.0050819	0.0409511	0.9012379
Simple mode	23	0.0735821	0.1140842	0.5256094
Weighted mode	23	0.0450353	0.0858854	0.6052683

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.18929	21	0.2839777
Inverse variance weighted	24.23743	22	0.3349078

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012381	0.0060556	0.8399719

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000735	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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