Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1339)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0678504	0.1034690	0.5191019
Weighted median	23	0.0006797	0.0549342	0.9901281
Inverse variance weighted	23	0.0344555	0.0396275	0.3845824
Simple mode	23	0.0118409	0.0792801	0.8826341
Weighted mode	23	0.0079735	0.0608366	0.8969160

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.56321	21	0.3677015
Inverse variance weighted	22.69531	22	0.4191014

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020508	0.0058485	0.7293465

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007113	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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