Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1338)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0472320	0.1011191	0.6452438
Weighted median	23	0.0511031	0.0573753	0.3731003
Inverse variance weighted	23	0.0413988	0.0390156	0.2886526
Simple mode	23	0.0166045	0.0826161	0.8425575
Weighted mode	23	0.0361087	0.0618965	0.5655752

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.54994	21	0.4258300
Inverse variance weighted	21.55397	22	0.4867651

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003582	0.0057157	0.9506208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006873	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8