Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1337)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2826044	0.0998194	0.0100046
Weighted median	23	0.1057484	0.0544454	0.0521028
Inverse variance weighted	23	0.0667816	0.0404506	0.0987508
Simple mode	23	0.1161356	0.0895530	0.2081246
Weighted mode	23	0.1161356	0.0593769	0.0632925

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.13057	21	0.6407273
Inverse variance weighted	23.64834	22	0.3659288

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0132537	0.0056423	0.0286889

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008054	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8