Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1336)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0924973	0.1115217	0.4162004
Weighted median	23	-0.0173952	0.0576207	0.7627351
Inverse variance weighted	23	-0.0247312	0.0430266	0.5654351
Simple mode	23	-0.0083574	0.0985257	0.9331682
Weighted mode	23	-0.0261799	0.0584305	0.6584972

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.21213	21	0.1984756
Inverse variance weighted	26.75612	22	0.2206359

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041615	0.0063037	0.5163236

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008229	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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