Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1335)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1561100	0.0998203	0.1327839
Weighted median	23	0.0089736	0.0547866	0.8698947
Inverse variance weighted	23	0.0362752	0.0390156	0.3524946
Simple mode	23	-0.0102556	0.0938851	0.9140056
Weighted mode	23	-0.0065990	0.0622357	0.9165171

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.28089	21	0.6939448
Inverse variance weighted	21.66523	22	0.4800158

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0118143	0.0056423	0.0485844

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006827	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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