Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1334)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1506690	0.0998201	0.1460954
Weighted median	23	0.0512547	0.0545423	0.3473591
Inverse variance weighted	23	0.0219173	0.0390156	0.5742813
Simple mode	23	0.0844524	0.0891720	0.3538887
Weighted mode	23	0.0767763	0.0723486	0.3001107

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.55153	21	0.9235188
Inverse variance weighted	14.51520	22	0.8821902

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0079067	0.0056423	0.1757275

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004494	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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