Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1333)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1028735	0.0998209	0.3144615
Weighted median	23	0.0469132	0.0555670	0.3985227
Inverse variance weighted	23	0.0459940	0.0390157	0.2384535
Simple mode	23	0.0555709	0.1001766	0.5846760
Weighted mode	23	0.0381969	0.0693183	0.5871616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.84993	21	0.8759587
Inverse variance weighted	14.23316	22	0.8929976

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003493	0.0056424	0.5425346

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004734	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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