Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1332)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0065235	0.1120870	0.9541391
Weighted median	23	-0.0303250	0.0536708	0.5720604
Inverse variance weighted	23	-0.0331272	0.0428705	0.4396848
Simple mode	23	-0.0222281	0.0897145	0.8066144
Weighted mode	23	-0.0463226	0.0622698	0.4648079

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.47844	21	0.1887905
Inverse variance weighted	26.56228	22	0.2283248

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016337	0.0063357	0.7990246

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008268	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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