Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1331)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0652728	0.1065672	0.5467806
Weighted median	23	0.0014586	0.0528038	0.9779629
Inverse variance weighted	23	0.0079723	0.0412315	0.8466815
Simple mode	23	-0.0652792	0.0873083	0.4625672
Weighted mode	23	-0.0217479	0.0653482	0.7424355

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.9345	21	0.2962429
Inverse variance weighted	24.5700	22	0.3180762

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004498	0.0060237	0.4635155

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007458	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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