Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1330)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1803812	0.1311132	0.1833910
Weighted median	23	-0.0937219	0.0601310	0.1190844
Inverse variance weighted	23	-0.0572154	0.0512954	0.2646754
Simple mode	23	-0.1490197	0.1276429	0.2555172
Weighted mode	23	-0.1709574	0.0712931	0.0254077

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.23333	21	0.0205815
Inverse variance weighted	38.03045	22	0.0181782

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075637	0.0074113	0.319071

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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