Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 133)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0079529	0.0998211	0.9372528
Weighted median	23	0.0218563	0.0517242	0.6726209
Inverse variance weighted	23	0.0521516	0.0390158	0.1813278
Simple mode	23	0.0254731	0.0838010	0.7640059
Weighted mode	23	0.0345885	0.0650456	0.6002228

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.40764	21	0.9542487
Inverse variance weighted	11.63905	22	0.9643919

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027142	0.0056424	0.6354581

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004068	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8