Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1329)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1342419	0.1003856	0.1954424
Weighted median	23	-0.0437302	0.0561757	0.4363012
Inverse variance weighted	23	-0.0167888	0.0397817	0.6730084
Simple mode	23	0.0484463	0.1114203	0.6679379
Weighted mode	23	-0.0120414	0.0900061	0.8947891

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.23872	21	0.4444509
Inverse variance weighted	22.87287	22	0.4089377

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072128	0.0056743	0.2175804

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006987	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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