Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1328)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0843145	0.1063111	0.4365936
Weighted median	23	0.1003594	0.0573227	0.0799840
Inverse variance weighted	23	0.0775379	0.0406020	0.0561706
Simple mode	23	0.1613623	0.0965315	0.1087677
Weighted mode	23	0.1126100	0.0604195	0.0757511

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.82015	21	0.3018540
Inverse variance weighted	23.82559	22	0.3564375

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004161	0.0060092	0.9454446

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8